3.5 Viruses

Programme Title: Possum Viruses
Programme Leader: Dr Joseph O’Keefe
Institution: AgResearch, Wallaceville

 

Programme Goal: To isolate, characterise and genetically manipulate possum viruses for the biological control of possums.

Objective 1

Objective Title: Possum Viruses
Research Leader: Dr Joseph O’Keefe

Description:

Isolation, characterisation and genetic manipulation of possum viruses for the biological control of possums by;

  • Establishing a model system of herpesvirus infection (specifically MHV-1) and using it to develop methods to infect, producing an immune response, establishing a latent infection and to reactivate virus in brushtail possums
  • Combining existing techniques and those developed in the model system to identify naturally occurring herpesvirus infections in brushtail possums.
  • Addressing the classification of the causative agent of wobbly possum disease through the use of molecular techniques, such as subtractive hybridisation methods.
  • Establishing a collaboration with an overseas laboratory with the aim of gaining further knowledge about wobbly possum disease virus and its relationship with Borna disease virus.
  • Investigating outbreaks of disease in possums that may be of viral origin with the aim of isolating and characterising new viruses.

Objective 2

Objective Title: Isolation and characterisation of possum adeno viruses.
Research Leader: Dr Joanne Meers (Massey University)

Description

The goal of this work is to develop a virus which can be used as a vector of foreign DNA encoding a gene which can inhibit possum reproduction. The immediate aims of this objective are to isolate and characterise possum adeno viruses.

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